1982 marked the fruition of a young couple's dream to actualize the vision of St. Anthony Mary Claret: to produce leaders with virtues through education. Thus, Saint Anthony Learning Center was established. Years later, as the institution expanded in terms of infrastructural development and student growth, its name was changed to the School of Saint Anthony (SSA.)  Fueled by the passion to spread its brand of quality education, the College of Saint Anthony (CSA,) in the City of San Jose del Monte, Bulacan, in 2008, was established.

While the initial plan was for CSA to offer tertiary programs, a shift to basic education was made in response to the community's clamor for a good basic education provider within the neighborhood. Soon after, the basic education department was in full swing from preschool to grade 10, preparations of CSA were directed to the senior high school (SHS) program in response to the K to 12 initiative of the Department of Education.

Finally, with the basic education program in place, CSA began its application for tertiary education. This decision was made synchronous to the school's 10th founding anniversary. Several degree programs in the fields of Education, Accountancy, and Multimedia Arts were eventually approved by the Commission on Higher Education (CHED) for initial operations. 

CSA fully recognizes its uniquely talented students by providing them with student-centered, engaging, and values-based learning opportunities. Through constant exposure to both on-campus and off-campus activities, Anthonians are able to gain confidence, optimism, compassion, and humility whilst developing skills that will help them find their place in the world. Here, they are encouraged to challenge themselves beyond their expected level of performance, increasing their experiences of success in a variety of learning areas.